Commentary: Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): Remember Your ABCs (Airway, Breathing, Circulation).

Corresponding E-Mail: [email protected] Clinical Perspectives R Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is a devastating disorder that manifests in seemingly normal children, most typically between two and nine years of age. Because of the unique constellation of symptoms comprising the ROHHAD phenotype and inadequate public and medical awareness of the entity, diagnosis of affected children is often delayed and intervention is repeatedly incomplete and unsustained. Extensive experience with ROHHAD patients in the Center for Autonomic Medicine in Pediatrics (CAMP) at Ann & Robert H. Lurie Children’s Hospital of Chicago and the International ROHHAD Research Consortium informs us that children without early and adequate support of their hypoventilation (providing an adequate airway and breathing support) and anticipatory management of the ROHHAD phenotype (with particular attention to fluid balance and circulation) are most likely to have significant behavioral issues, deterioration, and heightened risk for sudden death.